![]() ![]() ![]() Statistical significance of microRNAs and genes analysis results was evaluated using DESeq2 and uninformative variable elimination by partial least squares methods. High-throughput sequencing was employed to examine microRNAome and transcriptome of peripheral blood mononuclear cells of patients with LEAD, in relation to controls. We aimed to indicate the most promising microRNA and gene expression signatures of LEAD, to identify interactions between microRNA and genes and to describe potential effect of modulated gene expression. MicroRNAs belong to epigenetic factors that regulate gene expression and have not yet been extensively studied in LEAD. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. ![]()
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